This article needs additional citations for verification. In 1545, claude de Lorraine, premier duc de Guise PDF was seriously wounded at the Second Siege of Boulogne, but recovered. He was struck with a lance through the bars of his helmet.
In 1548 he was magnificently wedded to Anna d’Este, daughter of the Duke of Ferrara, Ercole II d’Este, and French princess, Renée, the daughter of Louis XII. In 1551, he was created Grand Chamberlain of France. Guise family, and the Grand Master of France Montmorency was disgraced and sent from court. However, the king died on 5 December 1560—making Mary, Queen of Scots a widow, and of little political importance. The Guises lost status alongside her, thus making a year full of calamity for the Guises both in Scotland and France. Within a year and a half, their influence waxed great and waned. The regent, Catherine de’ Medici, was at first inclined to favour the Protestants.
To defend the Catholic cause, the Duke of Guise, together with his old enemy, the Constable de Montmorency and the Maréchal de Saint-André formed the so-called triumvirate opposed to the policy of concessions which Catherine de’ Medici attempted to inaugurate in favour of the Protestants. The plan of the Triumvirate was to treat with Habsburg Spain and the Holy See, and also to come to an understanding with the Lutheran princes of Germany to induce them to abandon the idea of relieving the French Protestants. About July, 1561, Guise wrote to this effect to the Duke of Württemberg. It is not known to what extent he was responsible for this, but the Massacre of Vassy kindled open military conflict in the French Wars of Religion.
In the fourth encounter, Guise was about to take Orléans from the Huguenot supporters of Condé when he was wounded on 18 February 1563 by the Huguenot assassin, Jean de Poltrot de Méré, and died six days later, bled to death by his surgeons, at Château Corney. It was not the first plot against his life. Guise’s unexpected death temporarily interrupted open hostilities. In his testimony, Poltrot implicated Coligny and the Protestant pastor Théodore de Bèze.
Guise married Anna d’Este, daughter of Ercole II d’Este, Duke of Ferrara, and Renée of France, in Saint-Germain-en-Laye on 29 April 1548. Peter II de Luxembourg, Count of St. Eric Durot, François de Lorraine, duc de Guise entre Dieu et le Roi, Paris, Classiques Garnier, 2012. Froude, James Anthony, History of England, v.